Amtrak revived the name for a new Grand Rapids–Chicago service on August 5, 1984,[7] with financial support from the state of Michigan.

[11] On November 30, 2007, the southbound Pere Marquette collided with a Norfolk Southern freight train in Chicago, injuring 71 people.

The National Transportation Safety Board (NTSB) determined that the probable cause of the collision was the failure of the Amtrak engineer to interpret the signal at Englewood interlocking correctly and Amtrak's failure to ensure that the engineer had the competence to interpret signals correctly across the different territories over which he operated.

[12] In March 2020, the Pere Marquette was suspended indefinitely as part of a round of service reduction in response to the ongoing COVID-19 pandemic.

Around 2021, MDOT initiated the design and engineering needed to connect the Amtrak Michigan Line to the CSX tracks north of New Buffalo station.