Honig's work is concerned with the relationship between pop culture, sexual vulnerability, social anxieties, the ethics of luxury, and trends in consumerism.
[3] At age 22, Honig was the youngest living artist to have work acquired by the Whitney Museum of Art's permanent collection.
In 1997, Honig started Fahrenheit Gallery, an artist-run space in Kansas City's industrial West Bottoms, where she showed artists with national and international reputations and inspired other young Kansas City artists to do the same.
[5] Honig owns a lingerie and swimwear boutique, Birdies,[6] which opened in 2003, and is located in the Crossroads Section of Kansas City, Missouri.
Early sexual awakenings, the visual manifestation of disease, and the social anxieties of realized and fictional characters reveal themselves through Peregrine Honig's drawings and paintings.