These brachiopods are stationary epifaunal suspension feeders, its most distinguishing feature is the size, considered to be the largest of all Mesozoic rhynchonellids, which has long puzzled paleontologists because of its unusual morphology, stratigraphic occurrence, and distribution patterns.

[1] Fossils of the genus have been found in:[2] Limestones yielding Peregrinella frequently occur as large detached blocks occasionally displaying strong calcification and silification.

[4] In combination with the lowest δ13C carbonate values of -6.9% found for the Curnier Limestone, the observed lipid patterns are best explained by anaerobic oxidation of methane at a seafloor seep.

[4] Peregrinella has long been viewed as a paleontological curiosity because of its distinctive morphology, anomalous stratigraphic associations, and extensive, yet discontinuous paleogeographic distribution throughout Early Cretaceous continental margin areas of western North America and Tethyan Eurasia.

[1] After analyzing data from various locations, Sr-isotope stratigraphic investigation confirms that oldest and youngest biostratigraphically well-dated occurrences as late Berriasian and early Hauterivian, respectively.