The Palacio Pereira is a historic neoclassical mansion located at the corner of San Martín and Huérfanos streets, in downtown Santiago, Chile.

Luis Pereira Cotapos, a wealthy lawyer, wine company owner and Chilean politician, wanted to build a palatial house similar to those found in the Barrio Dieciocho.

Later the building was leased by the Ministry of Education, beginning its deterioration phase when it was altered to serve as a high school (Liceo N° 3 de Niñas) between 1950 and 1968.

[5] Following the 1973 Chilean coup d'état, the Inmobiliaria San Luis acquired the palace, subdividing it into several stores for rent, damaging the building.

The project was awarded to the team of the architect Cecilia Puga, along with Paula Velasco and Alberto Moletto, and was executed and financed by the Ministry of Public Works, through its Architecture Department.

[7] The restoration project includes the removal of the superficial layer of paint on the walls, leaving exposed the original colors.

Another planned task is the construction, on an empty plot of land adjacent to the original building, of a reinforced concrete structure with five above-ground stories and two basement levels, adding 4675 m² of floor space for the offices of the Dirección de Bibliotecas, Archivos y Museos (DIBAM) and the Consejo de Monumentos Nacionales (CMN); thus, the palace will have a total floor area of 6467 m².

[8] In 1872, the French architect Lucien Hénault was appointed by Luis Pereira Cotapos to design and built the palace.