Perforating folliculitis is a skin condition in humans characterized by discrete follicular keratotic eruptions involving mainly the hairy parts of the extremities.
[2] Primary lesions of perforating folliculitis typically have scaly, folliculocentric papules that are 2 to 8 mm in diameter, tiny central keratotic plugs, and various degrees of erythema.
The more prevalent relationship with chronic renal failure suggests a pathogenetic link, while some associations may just be coincidental.
[4] In cases of perforating folliculitis, the affected hair follicle has a transepithelial channel and, frequently, a parakeratotic luminal plug as well as focal destruction of its lateral wall.
In this transfollicular channel and in the follicular lumen, parakeratotic keratin is combined with connective-tissue components, such as collagen and elastin, and a variety of inflammatory cells.