[2] The disease is distinguished by large papules with central keratin plug on the skin, usually on the legs of the patient and is often in conjunction with liver, kidney or diabetic disorders.

The disease seems to be more prevalent in African Americans, which can be correlated to the high incidence of diabetes mellitus and kidney failure in the population.

In time, these lesions grow up to a radius of 0.75 inch and develop into red-brown nodules with a central plug of keratin.

The only correlation that has shown light is the frequent association with an underlying disorder, such as, diabetes mellitus, chronic kidney disease, hyperlipoproteinemia, liver abnormalities, and congestive heart failure.

The theory that most scientists agree upon is that Kyrle disease is an elimination of keratin and other cellular material across the epidermis.

Keratinization in Kyrle disease form at the basilar layer that is lower than the normal proliferation region in the epidermis.

This causes an inflammatory response which results with the keratin, along with other cellular material and connective tissue, to be forced out the epidermis.

This is theorized because this step is a main reason for inflammatory responses in other skin diseases, such as, elastosis perforans serpiginosa and perforating collagenosis.

[4] UV irradiation can be utilized after curetting the hyperkeratosis with a combination medication treatment of oral retinoids, psoralen and Ultraviolet A radiation.

However, when three of the young adult members were closely examined, they had posterior subcapsular cataracts and two of those three developed multiple tiny yellow-brown anterior stromal corneal opacities.