He is assigned a new client: a gifted perfumer Anne Walberg (Emmanuelle Devos) whose skills at constructing and identifying scents are matched by her egotism, poor treatment of her drivers, and lack of tact.
Unlike most people, Guillaume stands up to Anne, and she requests him to be her sole driver as she lands a series of jobs requiring her skills across France, including the capturing of scents in a replication of a Paleolithic cave site in southern France, and blending new scents to mask an objectionable odour delaying the marketing of a new range of luxury handbags (where Guillaume intervenes to double her fee if she can overcome the problem in only 7 days).
Four years ago she had a stressful high-profile job designing three perfumes for a major company in the US, and trying to bluff her way through with no sense of smell, the third one was a failure with an unacceptable scent - this has ruined her reputation in that industry.
But, overcome by her loss of sense of smell, she takes sleeping pills in Guillaume's car on the return journey to Paris, and he speeds her to hospital at 180 km/h, saving her life but getting points on his licence that disqualify him from driving.
She confronts Guillaume - who has confided in his daughter that he will now not be able to afford a larger apartment - and he agrees to become her agent as she continues to work with a returning sense of smell, and wants to re-enter the perfume industry that spurned her.