The Perham House is a historic residence located in Maquoketa, Iowa, United States.

[2] Built about 1859, the two-story frame house features a gable roof, full entablature creating a triangular pediment, pilastered corners, and a small wing on the west side.

Russell Perham was a New York native who settled in Maquoketa in 1858, and bought this property a year later.

Russell Perham was engaged in the mercantile and milling business, and served as the Justice of the Peace.

This article about a property in Jackson County, Iowa on the National Register of Historic Places is a stub.