Perillyl alcohol and its precursor limonene are naturally occurring monocyclic terpenes derived from the mevalonate pathway in plants.

Perillyl alcohol can be found in the essential oils of various plants, such as lavender, lemongrass, sage, and peppermint.

[3] Perillyl Alcohol decrease production of proangiogenic growth factors VEGF and interleukin-8 (IL-8) in vitro.

[4] Mammals possess enzymes (P450, liver) to convert limonene to Perillyl alcohol.

Conversion of limonene to perillyl alcohol is done via hydroxylation by enzymes that belong to the superfamily of cytochrome P450 proteins.