Perle Reid Mesta (born Pearl Skirvin; October 12, 1882 – March 16, 1975) was an American socialite, political hostess, and United States ambassador to Luxembourg (1949–53).

She was the inspiration for Irving Berlin's musical Call Me Madam, which starred Ethel Merman as the character based on Mesta in both the Broadway play and the movie.

In a 2009 essay by Thomas Mallon, Mesta has been identified as a model for the character Dolly Harrison in Allen Drury's 1959 novel Advise and Consent.

[5] Mesta is most noted for her festive parties, which brought together senators, congressmen, cabinet secretaries and other government figures in bipartisan soirées of high-class glamour.

She was apparently the inspiration for the Black Russian cocktail when the bartender at the Hotel Metropole in Brussels decided to make a signature drink for her.