His weekly Manna-fest with Perry Stone TV program, which focuses on Biblical prophecy, began airing on the Trinity Broadcasting Network in 2000.

[4] Over the years, Stone has claimed to have received prophetic visions about significant events, such as George W. Bush being elected president, the 9/11 attack on the World Trade Center, and Osama Bin Laden's death.

[12] In a 2018 appearance on evangelist Jim Bakker’s television program, Stone claimed that a government intelligence officer, who was a member of his father's church in northern Virginia, possessed the true knowledge of the Watergate scandal.

[13] In 2018, Stone claimed to have information about 64,000 emails that proved that the Democratic party conspired with Russia to defeat Donald Trump in the 2016 presidential election.

At the same time, Stone dismissed the virus as "media hype, God's retribution on the Chinese," and an excuse for the U.S. government "to implement widespread surveillance of citizens" via the implanting of a microchip that would serve as the Mark of the Beast.

[17] In April 2020, the Voice of Evangelism board of directors reportedly received letters from eleven individuals, nine of whom were women connected to Stone's ministry, that detailed allegations of sexual harassment and assault.

"[20] The board of directors instructed Stone to take a sabbatical for actions "that deviated from the biblical standards set in place for VOE leadership.

"[18] In December 2021, a Chattanooga, Tennessee, newspaper reported that the FBI was investigating Stone for the sexual misconduct allegations against him, his finances, and his connections to local law enforcement.