The Perry Wiles Grocery Company is a historic commercial building in downtown Zanesville, Ohio, United States.

Unlike many similar contemporary buildings in the city, it has survived to the present day relatively unchanged, and it has consequently been designated a historic site.

Finding the construction of a new building necessary in the early 1890s, Wiles arranged for the services of leading local architect Henry C. Lindsay.

[3] Although it features some modern elements, such as a cast-iron storefront, the building remains an obvious example of the Romanesque Revival style of architecture.

While the headquarters of the five grocery wholesalers may not have been significantly different in their heyday, the passage of time has greatly changed their appearance: the other buildings have all been destroyed or heavily modified, leaving the Wiles Block as Zanesville's only grocery wholesaler building that retains the appearance of a century before.