Perrysburg is a hamlet, census-designated place, and former village in Cattaraugus County, New York, United States.

A settlement has been located in the general area of the current village since the early 19th century.

[3] In 1910, the city of Buffalo, beset by the public scourge of tuberculosis, purchased almost 300 acres (1.2 km2) of land adjacent to the village using proceeds from Mayor James Noble Adam's personal fortune, for the purpose of establishing the Buffalo Municipal Hospital for Incipient Tuberculosis.

Since the hospital closed its doors, a popular local legend holds that a stained glass dome in the Hall Rotunda was salvaged from the Temple of Music at Buffalo's Pan-American Exposition.

On March 16, 2010, voters approved, by a 60-9 margin, a referendum to dissolve the village into the town of Perrysburg.

Perrysburg joined Randolph, East Randolph and Limestone among Cattaraugus County villages that voted to dissolve within a six-month span, with all but Limestone having approved their dissolutions on March 16.

[7] According to the United States Census Bureau, the village has a total area of 1.0 square mile (2.6 km2), all land.