[8] Tuscumbia is located in central Miller County on the north bank of the Osage River, near the junction of Missouri routes 17 and 52.

According to the U.S. Census Bureau, Tuscumbia has a total area of 0.35 square miles (0.91 km2), all land.

[1] As of the census[10] of 2010, there were 203 people, 55 households, and 38 families living in the village.

There were 70 housing units at an average density of 200.0 per square mile (77.2/km2).

25.5% of all households were made up of individuals, and 9.1% had someone living alone who was 65 years of age or older.

24.6% of all households were made up of individuals, and 15.8% had someone living alone who was 65 years of age or older.

About 12.0% of families and 19.3% of the population were below the poverty line, including 35.7% of those under the age of eighteen and 36.8% of those 65 or over.