Persiculinae is a taxonomic subfamily of minute to small predatory sea snails, marine gastropod mollusks.

(Note: Gastropod taxonomy has been in flux for more than half a century, and this is especially true currently, because of new research in molecular phylogeny.

In 2019 this subfamily has been classified as a synonym of the subfamily Cystiscinae Stimpson, 1865 [1] The shell minute to large, white, uniformly colored, or patterned; spire immersed or low to tall; lip thickened, smooth or lirate; external varix present or absent; siphonal notch present or absent; weak to distinct posterior notch present; columella multiplicate with combined total of 3 to 13 plications plus parietal lirae; internal whorls cystiscid type.

Animal with short to long tentacles, rarely absent; siphon short to long; eyes situated laterally on head slightly below the base of the tentacles; mantle usually not extending over external shell surface.

Odontophoral cartilages separate; valve of Leiblein present, with or without bypass tube; esophageal caecum absent; gland of Leiblein short, small, emptying directly into posterior end of esophagus; paired salivary glands ascinous or tubular, attached to esophagus just anterior to the valve of Leiblein, ducts attached to walls of esophagus; single accessory salivary gland present, ascinous or tubular, anal gland absent.