The duct persists as a midline structure forming an open connection between the back of the tongue and the thyroid gland.

Studies done on cadavers claim persistent thyroglossal ducts can be completely asymptomatic and found in 7% of the human adult population.

Local infections, such as colds, tonsillitis, or inflammation of the lymph nodes in the area can also lead to the accumulation of fluid within the duct.

[citation needed] Three-fourths of abnormalities within a persistent thyroglossal duct involve the formation of a cyst.

As the developing thyroid begins to travel to its intended destination, it remains connected to the tongue via the thyroglossal duct.

However, in the case of a persistent thyroglossal duct, the tube remains hollow and continues to connect the foramen cecum to the thyroid gland.

A persistent thyroglossal duct in a rabbit showed resemblance to the layout of the alimentary canal; with its external fibrous connective tissue, muscular layers, submucosal glands, and convoluted epithelium.

[6] In order to prevent further cysts and infections from forming, the thyroglossal duct and all of its branches are removed from the throat and neck area.

The Sistrunk procedure has a reoccurrence rate of less than 5%, proving it is extremely effective at removing the majority of traces of the persistent thyroglossal duct.