Thyroid dyshormonogenesis is a rare condition due to genetic defects in the synthesis of thyroid hormones.

[1][2] It is due to either deficiency of thyroid enzymes, inability to concentrate, or ineffective binding.

[citation needed] This is due to inability to produce thyroid hormones due to congenital absence of peroxidase or dehalogenase enzymes[citation needed] One particular familial form is associated with sensorineural deafness (Pendred's syndrome).

[citation needed] OMIM includes the following: These patients respond well to levothyroxine (synthetic T4) and the goiter may decrease in size if any.

This article about an endocrine, nutritional, or metabolic disease is a stub.