[1] Joker, the game's protagonist, is able to wield multiple Personas, which are gained through random drops or by defeating named mini-bosses in dungeons.

Exploring dungeons is similar to Persona 5, where players can use stealth to avoid enemies or may occasionally face the need to solve puzzles to progress.

Four months after the events of Persona 5, the protagonist and Morgana return to Tokyo for a reunion with the other Phantom Thieves of Hearts to spend their summer vacation together on a camping trip.

Despite their celebration, during that night, Lavenza appears as the Velvet Room's sole resident and warns the protagonist of a "potential calamity" that may "consume the world whose heart he strove so greatly to change".

While going to Shibuya to buy the necessary tools, they pass by an aspiring idol, Alice Hiiragi, who gives the protagonist an invitation card and requests them to input "Wonderland" into the EMMA app for a special event she is holding.

Alice's Shadow has the protagonist, Morgana, and Ryuji thrown into a dumpster below Shibuya, where they encounter a sentient AI named Sophia.

Zenkichi blackmails them into making a deal with him: he will provide them with information necessary for their heists, and in exchange, the Phantom Thieves will help him with his investigation, which they reluctantly agree to.

After infiltrating an abandoned Jail in Okinawa and learning of the origins of EMMA's Jail-creating powers, the Thieves are branded as terrorists by Owada and Konoe, who both call for their arrest.

Upon seeing his daughter's hatred and resentment towards him as a result of his being unable to bring Owada to justice, Zenkichi succumbs to an emotional breakdown and eventually awakens his own Persona, Valjean.

After Zenkichi reconciles with his daughter, The Thieves then request help from Ichinose to gain more information about EMMA and Madicce, eventually allowing them to enter Konoe's Jail in Osaka.

While tracking EMMA to the Tokyo Tower, the Thieves find and confront a god-like AI at the top of a newly created Jail, the Tree of Knowledge.

Unwilling to accept a world where their struggles mean nothing, the Phantom Thieves free the people of Tokyo from EMMA's grasp with a virtual calling card and defeat the Demiurge in the final battle.

In the aftermath, Owada is arrested thanks to Konoe's testimony, Zenkichi thanks them for their assistance in the case, and returns to Kyoto to reunite with Akane, and Sophia decides to go on a journey of self-discovery together with Ichinose.

[4][5] It was co-developed by Koei Tecmo's Omega Force studio and Atlus' P-Studio, and released for the Nintendo Switch and PlayStation 4 in Japan on February 20, 2020, as Persona 5 Scramble: The Phantom Strikers.

[6] It was produced by Daisuke Kaneda and Kenichi Ogasawara, with music composed by Atlus' Atsushi Kitajoh and Koei Tecmo's Gota Masuoka and Ayana Hira.

[23] Michael Higham of GameSpot wrote that "Persona 5's RPG elements thrive in action-based combat, and while the story may not hit hard, the Phantom Thieves haven't forgotten what they're about.

[29] In the United States, Persona 5 Strikers was the third best-selling game of February 2021, after Super Mario 3D World + Bowser's Fury and Call of Duty: Black Ops Cold War.