Perza Rodríguez Quiñones (born July 14, 1957) is a Puerto Rican politician and former mayor of Cabo Rojo.

Since her childhood, Perza developed a friendship with Santos Padilla, who would later become Mayor of Cabo Rojo, and her boss.

She then enrolled at the University of Puerto Rico at Mayagüez where she completed a Bachelor's degree in Business Management, graduating in 1979.

In 1980, Perza began working for BAL Management Corp. in the administration of public housing buildings with federal funds (HUD).

Rodríguez was hired to work at the Center of Collection of Municipal Taxes (CRIM) by Santos "San" Padilla as appraiser in the Mayagüez office.