The first of the three is a single and short-term very high level of exposure which can be experienced by individuals who die by suicide, as well as pesticide formulators.

[6] Self-poisoning with agricultural pesticides represents a major hidden public health problem accounting for approximately one-third of all suicides worldwide.

[12][13][14] Exposure can occur through inhalation of pesticide fumes, and often occurs in settings including greenhouse spraying operations and other closed environments like tractor cabs or while operating rotary fan mist sprayers in facilities or locations with poor ventilation systems.

[6] Most occupational exposures are caused by absorption through exposed skin such as the face, hands, forearms, neck, and chest.

[22] Besides acute symptoms including cholinergic crisis, certain organophosphates have long been known to cause a delayed-onset toxicity to nerve cells, which is often irreversible.

Several studies have shown persistent deficits in cognitive function in workers chronically exposed to pesticides.

[23] Most pesticide-related illnesses have signs and symptoms that are similar to common medical conditions, so a complete and detailed environmental and occupational history is essential for correctly diagnosing a pesticide poisoning.

When handling or applying pesticides, exposure can be significantly reduced by protecting certain parts of the body where the skin shows increased absorption, such as the scrotal region, underarms, face, scalp, and hands.

[28] Exposure can be significantly reduced when handling or applying pesticides by protecting certain parts of the body where the skin shows increased absorption, such as the scrotal region, underarms, face, scalp, and hands.

[36] Studies have shown that it can reduce the amount absorbed if given within 60 minutes,[37] though there is not enough data to determine if it is effective if time from ingestion is prolonged.

[38] Urinary alkalinisation has been used in acute poisonings from chlorophenoxy herbicides (such as 2,4-D, MCPA, 2,4,5-T and mecoprop); however, evidence to support its use is poor.

"Most estimates concerning the extent of acute pesticide poisoning have been based on data from hospital admissions which would include only the more serious cases.

Farm workers are impacted greatly and though they get treatment once they are exposed they have to deal with other health issues even years after the incident.

Farmers and everyone in surrounding areas of pesticide poisoning are exposed and at risk of all the long term effects.

[45] The neurotoxicity of certain pesticides has been implicated as a potential contributing factor to the development of neurodegenerative diseases, raising concerns about their long-term impact on human health.

[47] Rachel Carson's 1962 environmental science book Silent Spring brought about the first major wave of public concern over the chronic effects of pesticides.

[48] Pesticide drift is not an isolated occurrence and it happens routinely to those working in the fields and farm-working neighborhoods that reside close to industrial farming.

[49] The problem this presents is that in order to obtain the same desired effect of the pesticides they have to be made increasingly stronger as time goes on.

Repercussions of the use of stronger pesticides on vegetation has a negative result on the surrounding environment, but also would contribute to consumers' long-term low-level exposure.