He is best known for his portrayal of Barry on Grace and Frankie and operational psychologist Nate Getz on the CBS show NCIS: Los Angeles.

[1] Cambor studied at Deerfield Academy in Massachusetts[2] and at Wesleyan University[3] in Middletown, Connecticut, where he earned a BA degree in English in 2001.

Cambor landed the lead as an expectant father on Notes from the Underbelly after the sitcom's creator saw his performance in a Los Angeles production of The Cherry Orchard opposite veteran actors Annette Bening and Alfred Molina.

Between 2009 and 2023, Cambor appeared as a recurring cast member on NCIS: Los Angeles as Nate Getz, an operations psychologist in the Office of Special Projects.

He was an executive producer on the Quibi documentary series "Blackballed", about Donald Sterling's expulsion from the NBA for racist comments he made during the 2014 season.