He transferred into the architecture school as an undergraduate at Cornell University and gave up his position on the swimming team in order to commit full-time to his studies.

[citation needed] He first rose to prominence as a member of the New York Five (also known as "the Whites"), along with fellow architects Charles Gwathmey, John Hejduk, Richard Meier, and Michael Graves.

Some examples include the Memorial to the Murdered Jews of Europe in Berlin[7] and the new University of Phoenix Stadium in Glendale, Arizona.

[citation needed] His writings have pursued topics including comparative formal analyses; the emancipation and autonomization of architecture; and histories of Architects.

These include his English mentor Colin Rowe, the Italian historian Manfredo Tafuri, George Baird, Fredric Jameson, Laurie Olin, Rosalind Krauss and Jacques Derrida.

It was frequently repeated that the Wexner's colliding planes tended to make its users disoriented to the point of physical nausea; in 1997 researcher Michael Pollan tracked the source of this rumor back to Eisenman himself.

In architectural historian Andrew Ballantyne's opinion, "By some scale of values, he was actually enhancing the reputation of his building by letting it be known that it was hostile to humanity."