He also starred on the USA Network science fiction drama Colony as former Proxy Snyder.

[3] Jacobson and Lisa Edelstein, his future co-star on House, appeared as a couple eating at a restaurant in the 1997 film As Good as It Gets.

He appeared twice on Law & Order as Randy Dworkin, a jovial crusading defense attorney.

[4] He has appeared in Scrubs, CSI: Miami, The Lost Room, The Starter Wife, Transformers, Colony, and The Midnight Meat Train.

[5] He made a guest appearance as Alan on an episode of the USA Network's Royal Pains.