In October 2002, in front of a packed arena of fans at the Dunkin Donuts Center in his hometown of Providence, Manfredo Jr. stepped up in weight class and won a seventh-round TKO over former WBC and WBA Light Welterweight champion Frankie “The Surgeon” Randall.
In January 2004, he went on to win the NABO Junior Middleweight title in a sixth-round fight against the previously undefeated Sherwin Davis in an ESPN2 co-feature at Foxwoods Casino.
Many ringside observers felt Manfredo won the fight convincingly, but Mora was awarded a controversial split decision.
[5] Manfredo fought Scott Pemberton on February 2, 2006, to a sold out crowd in the Dunkin' Donuts Center in Providence, Rhode Island, on ESPN.
[6] One month later Manfredo easily defeated Ted Muller in a ninth round stoppage at Twin River Casino in Lincoln Rhode Island.
Manfredo's next fight was June 20, 2007, just one month after his previous victory over Muller, at Foxwoods Hotel and Casino, against tough veteran (14-1) David Banks, who was featured on season 3 of the Contender.
Manfredo then signed to fight former World Champion Jeff Lacy on December 8 at the MGM Grand Garden Arena, as the final bout on the undercard to the Floyd Mayweather vs Ricky Hatton main event.
[7] On March 14, 2008, Manfredo defeated Shane Benfield, then (29-5), at the Twin River Events Center in Lincoln, Rhode Island.
On January 29, 2010, Peter Manfredo defeated St. Paul Minnesota native Matt Vanda by unanimous decision (100–89, 100–89, 99-90) in a 10-round attraction at Mohegan Sun Casino in Ledyard, Connecticut.
The fight earned Manfredo a shot at the IBO Middleweight Title, which he won, when he defeated Mexican native Angel Hernandez on May 22, 2010.
[10] In November 2011, Peter Manfredo was stopped by Julio Cesar Chavez Jr in the fifth round of a WBC middleweight title bout.
Manfredo got hurt and referee Laurence Cole stepped in at 1:52 to end the fight, allowing Julio Cesar Chavez Jr to retain the title.
[11] In November 2012, Peter Manfredo Jr announced his return to boxing and defeated durable veteran Rayco Saunders in a dominant 10-round decision.