Palandjian attended Phillips Academy Andover and Harvard University, from which he graduated with a BA in Literature in 1987.

[2] Since 1993 he has been chief executive officer of Intercontinental Real Estate Corporation, which was originally a construction company and was founded in Boston in 1959 by his father, an immigrant to the United States, Petros A.

[4] Palandjian competed professionally after leaving college and won six ATP tour Challenger titles, all in doubles.

[7] Notable victories include wins over Jay Lapidus (Stratton Mountain, 1987), Ricardo Acuna and Mark Dickson (Raleigh, 1987) Tony Mmoh (Boston, 1998), Martin Laurendeau (Miami, 1998), Andrew Sznajder (Seattle, 1998).

[16] Since October 2023, Palandjian has faced criticism from pro-Palestinian activists for Intercontinental Real Estate Corporation's decision to lease one of its Cambridge, Massachusetts properties to the American subsidiary of Israeli defense company Elbit Systems.

[19] Activists have alleged that Intercontinental Real Estate Corporation leasing to Elbit Systems makes Palandjian complicit in genocide against Palestinians.

[20] Some activists have further highlighted Elbit Systems' role in providing weapons to Azerbaijan during the Nagorno-Karabakh conflict,[21][22] a conflict which culminated in accusations that Azerbaijan is committing genocide against Armenians,[23] and alleged that Palandjian should not allow Intercontinental Real Estate Corporation to lease space to Elbit Systems given his Armenian heritage.