Beginning in 1965 from semiotic and linguistic reflections (Austin, Jakobson, Peirce, Wittgenstein), Weibel developed an artistic language, which led him from experimental literature to performance.

In his performative actions, he explored not only the "media" language and body, but also film, video,[3] television,[4] audiotape and interactive electronic environments.

Besides taking part in happenings with members of the Vienna Actionism, he developed from 1967 (together with Valie Export, Ernst Schmidt Jr. and Hans Scheugl) an "expanded cinema" inspired by the American one and reflects the ideological and technological conditions of cinematic representation.

In 1966 he was with Gustav Metzger, Otto Muehl, Wolf Vostell, Hermann Nitsch and others a participant of the Destruction in Art Symposium (DIAS) in London.

From 1993 to 1999[11] he curated the Austrian pavilion at the Venice Biennale, after which took on curatorship and directorship at KMZ Arts and Media Centre in Karlsruhe, Germany.

Since January 1999 Peter Weibel has been Chairman and CEO of the ZKM Center for Art and Media in Karlsruhe, Germany.