[15] During the 2010 Ukrainian presidential election, Symonenko was the candidate of the Bloc of Left and Center-left Forces,[10][19][20][21][22] receiving 3.54% of the votes.

[24] In the 2014 Ukrainian presidential election, he initially ran as a candidate of his party on a federalization-platform that should have eventually led to a "parliamentary system without the institution of the presidency at all".

[13] He stated he withdrew "to save Ukraine from arbitrariness, which takes place today", and said about the elections itself "in our opinion they will be illegitimate".

[13] Later the same day, Symonenko's car was attacked by a mob with baseball bats and Molotov cocktails as he left a TV interview.

[27] In October 2022, Symonenko took part in the International Meeting of Communist and Workers' Parties in Havana, Cuba.

[28] In August 2023, the Security Service of Ukraine opened an investigation against Symonenko on the charges of sedition and treason.

[31] On 28 November 2006, the Ukrainian Parliament narrowly passed a law defining the Holodomor as a deliberate act of genocide and made public denial illegal.

Commenting in 2007, Symonenko said that he "does not believe there was any deliberate starvation at all", and accused Viktor Yushchenko of "using the famine to stir up hatred".