Returning from exile, he seized many political offices until he became the first absolute ruler of Siena.

After Pandolfo died in 1512, Borghese[2] succeeded him, only to be ousted by his cousin, cardinal Raffaello, with the help of Pope Leo X.

In the wake of more responsibilities from the Church, Raffaello ceded control of the city to his cousin, Francesco Petrucci.

Francesco was exiled after a successful coup by Pandolfo's youngest son, Fabio Petrucci.

Fabio was forced into exile by the Sienese people in 1525, marking the end of the Petrucci dynasty.