[3] Reed's directorial debut, the motion picture Bring It On, was a number one box office hit.

Peyton Reed was originally set to direct the 20th Century Fox production Fantastic Four, before departing the project and being replaced by director Tim Story.

Yes Man is an adaptation of Danny Wallace's autobiography about his decision to say "yes" to whatever offer, invitation, challenge, or opportunity that is presented to him.

[4] Prior to joining the production of Ant-Man, Reed was slated to direct a Brian Epstein biopic, based on the graphic novel The Fifth Beatle.

[8] Reed directed two episodes from the second season of the Disney+ series The Mandalorian, part of the Star Wars franchise.