Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy is a monthly peer-reviewed medical journal covering human pharmacology and pharmacotherapy, published by Wiley-Blackwell on behalf of the American College of Clinical Pharmacy, of which it is an official journal.

It was established in 1981 under founding editor-in-chief Russel R. Miller.

The second editor was Richard T. Scheife.

The third and current editor is C. Lindsay DeVane.

Initially published six times a year the journal has been a monthly since 1991.