1-Phenylpiperazine (1-PP or PP) is a simple chemical compound and drug featuring a phenyl group bound to a piperazine ring.

[1] The suffix ‘-piprazole’ is sometimes used in the names of drugs to indicate they belong to this class.

[3][4][5] 1-Phenylpiperazine shows toxicity at sufficiently high doses; its oral LD50 in rats is 210 mg/kg.

[6] Numerous derivatives of 1-PP, or substituted phenylpiperazines, exist.

[7][1] Some examples include meta-chlorophenylpiperazine (mCPP), 3-trifluoromethylphenylpiperazine (TFMPP), and para-methoxyphenylpiperazine (pMeOPP).