[1] Cuzzi made his major league debut on June 4, 1991, umpiring at first base in an 11-inning game between the St. Louis Cardinals and Los Angeles Dodgers.

[7] Cuzzi was the plate umpire for a game between the Boston Red Sox and Tampa Bay Rays on August 29, 2000.

[8] During the game, eight members of the Rays were ejected (seven by Cuzzi), but no Boston players were thrown out, something that reportedly had never happened before.

[10] In the top of the 11th inning of game 2 of the 2009 ALDS between the Minnesota Twins and the New York Yankees with no one out, Twins catcher Joe Mauer hit a ball that tipped off of left fielder Melky Cabrera's glove, landed fair, and bounced into the stands – Cuzzi called it a foul ball, denying Mauer of a ground rule double.

[11] This call proved to be costly as the Twins lost the game 4–3 on a walk-off home run in the bottom half of the inning.

[12] On August 17, 2019, Cuzzi was umpiring at first base when he ejected Yankees CC Sabathia and Brett Gardner.