Together, they presented the Sunday night entertainment show Dan and Phil on BBC Radio 1 from January 2013 until August 2014, and from September 2014 to April 2016 the duo were monthly hosts on the station's The Internet Takeover slot.

[7] Before making vlogging and radio presenting his full-time profession, Lester's early jobs included being a dog walker and car washer, working at a veterinary clinic and at WHSmith, and appearing in Faintheart.

In October 2014, it was announced that as of that month Lester and Howell would not carry on working on The Super Amazing Project to concentrate on their Radio 1 show.

Lester was interviewed with other internet entertainers on Channel 4 News in October 2012 about the increased popularity of YouTube and video blogging as a profession.

[34] From 2014 to 2016 Howell and Lester hosted the worldwide YouTube livestream of the Brit Awards as well as making backstage videos for their channel.

[35] In 2015, Lester and Howell had voice cameo appearances in the UK cinema release of Walt Disney Animation Studios' Big Hero 6 as Technician 1 & 2.

That same year, the duo also guest-starred in fellow YouTuber PJ Liguori's online series Oscar's Hotel for Fantastical Creatures, voicing anthropomorphic food items Brie and Rash.

[40] The duo had occasionally worked with Radio 1 before, making videos for the station's YouTube channel[41] and presenting two Christmas broadcasts.

The show was designed to be an interactive, audio-visual broadcast involving music videos made by viewers, physical challenges performed on air by Howell and Lester, and song requests from listeners.

[43] This new show was titled The Internet Takeover, and featured Lester alongside Howell live on the first Monday of every month, before coming to an end in April 2016.

In October 2017, the duo released a party board game via Big Potato, Truth Bombs, also the brainchild of Lester.

[2][49] The book topped the General Hardbacks Sunday Times Bestsellers list having sold 26,745 copies in the UK in the first week of its release.

[57][non-primary source needed] In October 2016, The Amazing Tour Is Not on Fire was released as a YouTube Red Original film by the same name along with a documentary, Dan and Phil's Story of TATINOF.

[61] Lester and Howell partnered with BBC Studios' TalentWorks to release a movie of Interactive Introverts with bonus features, such as behind the scenes content and director's commentary, on DVD, Blu-ray, and available for digital download in December 2018.

[64][63] In June 2024, Lester and Howell announced their third joint tour and first since the return of their gaming channel titled Terrible Influence, which would begin that September in Antwerp.

[70] In June 2019, Howell revealed that the two have been romantically involved but refrained from discussing their current relationship, stating "I'm somebody that wants to keep the details of my personal life private.