She began her career on the soap operas Days of Our Lives as Renée DuMonde and Another World as Donna Love Hudson.
[citation needed] In addition to her acting career, Sampler provided the voice to various characters in animated series, such as Toph Beifong in The Legend of Korra.
She also voiced characters in English-language dubs, such as Mimi Tachikawa and Cody Hida from Digimon: Digital Monsters, Tiptory in Eureka Seven, and Hiyori Tamura from Lucky Star.
After graduating from the University of North Texas in 1975 with a drama degree, Sampler moved to Hollywood and quickly landed guest roles in a few television movies and series, including The Incredible Hulk in season 4, episode 59 titled "Dark Side".
[citation needed] Sampler worked as associate producer of the Los Angeles stage hit Sordid Lives by Del Shores.