He grew up in Pittsburgh, where his father Anthony, the son of Italian immigrants, worked for the city and his mother, Helen (née Venditto), was a member of the school board.

He remained with Morgan Lewis until President Barack Obama appointed him to the National Labor Relations Board (NLRB) in April 2013.

[3] He returned to Morgan Lewis in February 2018 and leads the firm's NLRB special appeals practice.

Miscimarra is a senior fellow in the Wharton Business School's Center for Human Resources at the University of Pennsylvania.

[4] Miscimarra was named chair of the National Labor Relations Board (NLRB) by President Donald Trump on April 24, 2017, having served as acting chairman since January 23, 2017.