He began his professional career at Belgian clubs Beerschot and Genk between 1992 and 1998, thereafter he joined Coventry City in England for one season.

As a manager, Clement led Genk and Club Brugge to Belgian Pro League titles over three consecutive seasons.

Born in Antwerp, Clement played as a centre-back or defensive midfielder for Beerschot, Genk, Coventry City and Club Brugge.

[4] In November 2012, he had his first experience as a manager on a professional bench and took over on an interim basis for two games between the dismissal of Georges Leekens[6] and the appointment of Juan Carlos Garrido.

[15] His team lost the 2020 Belgian Cup final by a single goal to Royal Antwerp,[16] and made the last 32 in the Europa League before a 6–1 elimination by Manchester United.

[20] On 3 January 2022, Clement left Club Brugge after three seasons and joined Monaco of the French Ligue 1 as head coach, following the departure of Niko Kovač.

[23] In the space of two weeks in March, his team were eliminated from the Coupe de France semi-finals on penalties after a 2–2 draw again at Nantes,[24] and from the last 16 of the Europa League by Braga.

[29] He won the Scottish League Cup on 17 December with a single goal by James Tavernier in the final against Aberdeen, also taking his unbeaten run to 14 games in all competitions.