He was half of the duo Doppelganger with Randy Fredrix;[2] a video for their song "Communication Breakdown" was added to MTV's playlist in 1985.

He also worked with Nile Rodgers and Felicia Collins in the album Outloud and wrote for David Sanborn.

Although it did not reach the commercial success normally expected of an album boasting a cast of highly ranked musicians, it reunited Saisse with two old friends: bassist Pino Palladino, and drummer Simon Phillips.

The three performers joined together as an instrumental rock/jazz fusion trio ensemble PSP (Phillips Saisse Palladino).

Saisse was a member of Dave Koz & The Kozmos, the house band of The Emeril Lagasse Show.