The Philippine Carabao Center (Filipino: Sentro ng Kalabaw sa Pilipinas[2] or Sentro ng Pilipinas para sa Kalabaw[3]) an attached agency of the Department of Agriculture, was established at Science City of Muñoz in Nueva Ecija province in 1992 to breed and cross carabao based on high-yield Murrah buffalo (native breed of Haryana state of India) in the Philippines as a multi-purpose animal that can be raised for milk, meat, hide, and draft.

[4][5][6][7] It was set up in 1992 on a 40 hectares (99 acres) piece of land donated by Central Luzon State University on its main campus, initially with 6 network centers in 1992.

[8] On January 25, 2024, Francisco Tiu Laurel Jr. ordered the recall of Executive Director Liza Battad to the Philippine Carabao Center (who was appointed by William Dar in July 2021).

[11] The PCC had some success in reproductive biotechnology in 2004 when the first test-tube buffalo was born on April 5, also the birthday of President Gloria Macapagal-Arroyo.

Late in 2007, according to Filipino scientists, the Center located in Nueva Ecija initiated a study to breed the super water buffalo that could produce 4 to 18 liters of milk/day using gene-based technology.