Special issues have been devoted to topics as diverse as "Problems of the Self", "Existence: An East-West Dialogue", "Philosophy and Revolution", and "Environmental Ethics".

The journal was established in 1951 by Charles A. Moore as an outgrowth of the work of the East-West Philosophers' Conferences sponsored by the University of Hawaiʻi Department of Philosophy.

In 1967 the editorship passed to Eliot Deutsch, in 1986 to Roger T. Ames, and in 2017 to Franklin Perkins, all affiliated with the University of Hawaiʻi.

[1] Philosophy East and West appears quarterly in January, April, July, and October.

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