His mother was sister of Sir John Micklethwaite, physician to Charles II and to St. Bartholomew's Hospital.
He practised in London, residing in Little Britain, and was admitted a fellow of the College of Physicians 12 November 1680.
In 1684 he married Sarah, daughter of Sir Vincent Corbet, Baronet, at Shrewsbury.
He was learned in theology as well as in medicine, and was an admirer of Dr. Seth Ward, bishop of Sarum, whose views on passive obedience he warmly supported.
In some manuscript notes on a sermon of Ward's, on the text "And they that resist shall receive to themselves damnation", Fowke expresses his contempt of the conduct of the University of Oxford in 1688, saying, "These great pretenders to loyalty invited ye Prince of Orange.