In cases of pregnancy, it is most often seen during the third trimester, resulting from a compression of the left common iliac vein against the pelvic rim by the enlarged uterus.

[1] The condition can be identified clinically & as early as possible to prevent further deterioration & complications like embolism, ischaemic necrosis, and gangrene.

The diagnosis is confirmed with Doppler ultrasound of the veins of the affected leg, and occasionally other imaging modalities.

[citation needed] The mainstay of the treatment of deep vein thrombosis is with anticoagulation, but in very large DVTs various other modalities may be used to reduce the risk of complications.

[citation needed] Phlegmasia alba dolens literally means "painful white edema".