[2] In rats, ingested phlorizin is converted into phloretin by hydrolytic enzymes in the small intestine.

[6][7] It induces urea loss and diuresis when coupled with high protein diets.

Phloretin has been found to inhibit weight gain and improve metabolic homeostasis in mice fed with high-fat diet.

[9] Phloretin functionalized gold-nanoparticles (Pht-GNPs) were synthesized using a single-step synthesis method and tested for its anticancer activity.

Pht-GNPs showed significant cancer cell toxicities compared to free phloretin.