Dihydrochalcone

Dihydrochalcone (DHC) is the organic compound with the formula C6H5C(O)(CH2)2C6H5.

It is the reduced derivative of chalcone (C6H5C(O)(CH)2C6H5).

It is a white solid that is soluble in many organic solvents.

Dihydrochalcone per se is often minor significance, but some derivatives occur in nature and have attracted attention as drugs.

[1] Dihydrochalcones (3′,5′-dihydroxy-2′,4′,6′-trimethoxydihydrochalcone (methyl linderone) and 2′-hydroxy-3′,4′,5′,6′-tetramethoxydihydrochalcone (dihydrokanakugiol) can be found in twigs of Lindera lucida.

Chemical structure of dihydrochalcone
Chemical structure of dihydrochalcone
Neohesperidin dihydrochalcone is a commercial artificial sweetener that features the dihydrochalcone substituent.