The hospital provides comprehensive pediatric specialties and subspecialties including inpatient, outpatient, emergency, trauma, and urgent care to infants, children, teens, and young adults 0–21[2][3][4] throughout Arizona and the surrounding states.

In spring 2008, the hospital opened a new $23 million Neonatal Intensive Care Unit (NICU), which was one of the largest of its kind in the country.

[9] In 2016, Phoenix Children's was designated by the Arizona Department of Health Services as the only pediatric Advanced Life Support (ALS) Base Hospital in the state.

[11][12] In the spring of 2021, a building collaboration between Dignity Health and Phoenix Children's will be opening on the campus of Mercy Gilbert Medical Center.

[14][15] In March 2021, Phoenix Children's announced the building of a freestanding emergency department and specialty clinic in Avondale, Arizona, providing West Valley families convenient access to top-ranked care.

The campus includes a 71,250-square-foot multi-specialty clinic and an emergency department with 40 triage, treatment, and resuscitation patient rooms.

In May 2021, Phoenix Children's announced the building of a freestanding, 3-story hospital in Glendale, Arizona, which will offer inpatient care, an emergency department, an outpatient surgery center, and a multi-specialty clinic.

In February 2022, Phoenix Children's became a founding partner and official healthcare provider at Bell Bank Park, a $280 million multi-purpose sports and entertainment complex in southeast Mesa, Arizona.

The hospital also works in collaboration with Dignity Health and Mayo Clinic to provide more robust care in specialties related to cardiology, neurology, hematology/oncology and organ transplant.

The institute is located on the main campus of Phoenix Children's Hospital with satellite clinics across central Arizona.

It manages the majority voting member interest in Phoenix Children's Hospital and provides strategic planning, policy and oversight functions.