The 42-bed hospital was located east of downtown Chandler and quickly became poorly placed and too small for the area's large population increase in the 1970s and early 1980s.

After merging into Catholic Healthcare West, predecessor to Dignity Health, in 1999, a second tower was constructed to nearly double the number of beds.

Subsequent expansions in 2014 and 2021 have raised the number of beds to 429 in four patient towers and provided the facilities necessary for Level I trauma center status.

In June 1958, the state authorized a hospital district to include the area from Chandler to Queen Creek, which at the time contained 23,000 people—not counting residents and employees of Williams Air Force Base.

[5] The emergency room was not staffed around-the-clock; a patient needing to be admitted after hours had to ring a buzzer and wait for a doctor to be available.

[7] In June 1981, the hospital began seeking state approval to construct a new facility on land at Dobson and Frye roads.

[12] In the early years at the new facility, roads to the site remained dirt because real estate growth in the area had unexpectedly slowed.

[18] In December 1999, Chandler Regional merged into Catholic Healthcare West (CHW), under an arrangement that saw it remain a non-Catholic hospital.

[25] During the project, Chandler Regional announced it would pursue Level I trauma center designation, becoming the first such facility in the East Valley and fulfilling a longtime goal of local public officials.

[27] The five-story Tower D opened in July 2021 after four years of planning and construction, bringing the hospital to 429 patient beds including facilities for thoracic care and an expanded ICU.