Phosphatidylinositol-4-phosphate 5-kinase

Moreover, PIP5Kγ, has three splicing variance; PIP5Kγ635, PIP5γ661, and PIP5Kγ687, making it one of the key regulators for producing PI(4,5)P2 that plays a role in diverse cellular processes.

[10] A novel mechanism for the role of PIPKIα in regulating neuronal morphology by controlling microtubule dynamics is reported in mouse.

Growth cone formation is induced by Kinesin Supar Family protein 2A (KIF2A) KIF2A- mediated depolymerization of microtubules.

[11] In association with Daam2, PIP5 kinase promotes Wnt signaling and receptor complex formation which is required for the regenerative myelination of the neuron.

In the central nervous system (CNS) of chick, PIP5K-PI(4,5)P2 mediated role of Daam2 has been reported for the development of neurons.

Different types of PIP5 kinases and their subtypes
Role of PIP5K and PI(4,5)P2 in neuronal development PI(4,5)P2 is produced in different compartments of the cell from PI4P by PIP5 kinase. PIP5K and PI(4,5)P2 play important roles in neuronal development.