Phrom Khiri (Thai: พรหมคีรี, pronounced [pʰrōm kʰīː.rīː]) is a district (amphoe) of Nakhon Si Thammarat province, southern Thailand.

On 26 August 1974 the minor district (king amphoe) Phrom Khiri was formed with the three tambons Phrom Lok, Ban Ko, and In Khiri split from Mueang Nakhon Si Thammarat district.

[2] Phrom Khiri is located 16 km (9.9 mi) from Nakhon Si Thammarat Airport, and taking approximately 20 minutes to reach.

Neighboring districts are (from the north clockwise): Nopphitam, Tha Sala, Mueang Nakhon Si Thammarat, Lan Saka, and Phipun.

The Phrom Khiri district's motto is "The land of fruit, clean waterfalls, precious nature, a variety of folk wisdom, inherit the culture".