Phrom Phiram (Thai: พรหมพิราม, pronounced [pʰrōm pʰí.rāːm]) is a district (amphoe) in the northwestern part of Phitsanulok province, central Thailand.

In 1972 historians explored the old city area of Mueang Phrom Phiram.

The district office was moved to the right bank of the Nan River at Ban Yan Khat around 1950.

Phrom Phiram lies within the Nan Basin, which is part of the Chao Phraya Watershed.

Of the numerous villages in Phrom Phiram District, those that occupy several mubans are as follows: In 2006, there were reported cases of leptospirosis among residents of Phrom Phiram, contracted due to the amount of standing water.