Phutthaisong (Thai: พุทไธสง, pronounced [pʰút.tʰāj.sǒŋ]; Northeastern Thai: พุทไธสง, pronounced [pʰùt.tʰa᷇j.sǒŋ]) is a district (amphoe) in the northern part of Buriram province, northeastern Thailand.

Neighboring districts are (from the south clockwise) Khu Mueang of Buriram Province, Mueang Yang of Nakhon Ratchasima province, Ban Mai Chaiyaphot of Buriram, Nong Song Hong of Khon Kaen province, Na Pho of Buriram, Yang Sisurat and Phayakkhaphum Phisai of Maha Sarakham province, and Chumphon Buri of Surin province.

The Phutthaisong District's Motto is "Ancient moat, worship Big buddha image, beautiful silk, Sra Bau lake so Shady."

The district is divided into seven sub-districts (tambon), which are further subdivided into 97 villages (muban).

Missing numbers are tambon which now form Ban Mai Chaiyaphot district.