Quek was a full-time Mediacorp artist from 1995 to 2001, and was ranked by local media as the 'Fourth Ah Jie' for being the fourth most prominent actress in Singapore's Chinese-language entertainment industry of that time after Zoe Tay, Fann Wong and Ann Kok.
[3] In recognition of her popularity, local media crowned her as the Fourth Ah Jie, after Zoe Tay, Fann Wong and Ann Kok[4] In 2000, Quek starred alongside Hong Kong actors Aaron Kwok and Daniel Wu in the movie, 2000 AD.
The recording of the theme song of her earlier drama, The Other Parent (妈妈先生) and Mind Games (危险人物) marked the beginning of her career as a singer.
She then released her debut album, Phyllis, under Hype Records which contained primarily dance tracks and singles from the soundtrack of The Tree and Beyond The Axis Of Truth (法医X档案).
Throughout the 2000s, Quek starred in many regional productions from Taiwan and mainland China, including portraying the role of Yin Susu in The Heaven Sword and Dragon Saber (2003 TV series) co-starring Alec Su and Alyssa Chia.
After a seven-year absence from acting, Quek made her return in the 2017 drama Legal Eagles, portraying the role of an unscrupulous middle-aged businesswoman, Fang Hai Lun.